The Basic Input/Output System (BIOS) system installed on your computer is probably reducing the power to the port to which the input device is connected.

The Sleep key on your keyboard is not configured correctly.

Your system is not updated or you may be running Windows Vista.

Your computer has encountered a system problem.

The issue may be caused due to one or more of the following conditions: Why Your Computer Won’t Come Out of the Sleep Mode? When your computer gets stuck in Sleep Mode though, that's where the problem comes in. Thus, the programs you previously used would be running allowing you to move on with whatever it is you were working on right then and there. This would wake up the computer and would let you continue with whatever you were doing before it went to sleep. All you need to do is to press any key on your keyboard or move your mouse. When you need to use the computer again, you no longer have to boot it. You will be the one to set the time for it to sleep. When you set your computer to sleep mode, it would stop its functions on its own, after a certain time that it does not have any activity.

What you need to do When Windows 10 Won't Wake Up From Sleep.

Laptop not waking up from sleep